Acute myeloid leukemia, M2 with t8:21 translocation
نویسندگان
چکیده
منابع مشابه
A Rare Case of Acute Myeloid Leukemia with Translocation (3:3) Presenting with Features of Chronic Myelomonocytic Leukemia
Background: Acute Myeloid Leukemia (AML) with translocation (3,3) is a form of AML that may present de novo or may arise from a previous myelodysplastic syndrome. It is often associated with normal or elevated peripheral blood platelet count and increased bone marrow megakaryocytes with associated multi lineage dysplasia. A subset of patients present with hepatosplenomegaly while a few cases h...
متن کاملKIR2DS3 is Associated with Protection against Acute Myeloid Leukemia
Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...
متن کاملAcute myeloid leukemia with translocation t(3;5): new molecular insight
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متن کاملAcute myeloid leukemia with translocation t(3;5): new molecular insights.
AML with translocation t(3;5) belongs to the “AML with myelodysplasia-related changes” defined in the 2008 WHO classification. The incidence of this balanced abnormality is less than 0.5% of AML. The identified breakpoints occur at 3q25.1 on chromosome 3 and at 5q34 on chromosome 5, where the nucleolar phosphoprotein nucleophosmin 1 (NPM1) is located. At locus 3q25.1, Yoneda-Kato et al. identif...
متن کاملA rare cytogenetic presentation of acute myeloid leukemia (AML-M2).
Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t...
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ژورنال
عنوان ژورنال: Blood
سال: 1996
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v88.3.802.802